Clinical boundarySchedule I in the U.S.Serious cardiac riskNot FDA-approvedNo dosing or referrals

Evidence · condition

Cravings

LAST REVIEWED 2026-09-22 · OBSERVATIONAL · NOT CURE

Craving score changes can be observed without proving durable abstinence, broad efficacy, or safety.

Evidence: Limited observationalNot cureNo dosing

What exists (source-labeled)

Malcolm BJ et al., J Psychoactive Drugs 2018. PMID 29608409. See also Withdrawal for Alper/Lotsof PMID 10506904 and Mash PMID 11705106.

Broader OUD observational history: Mash et al. PMID 29922156.

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