IbogaBaseThe Iboga Evidence Base
Clinical boundary Schedule I in the U.S. Serious cardiac risk Not FDA-approved No dosing or referrals Schedule I · cardiac risk Not FDA-approved · no referrals

Evidence

Evidence by condition

LAST REVIEWED 2026-05-18 · 346 SOURCES · 0 CORRECTIONS

Evidence-grade pages use the same skeptical template: evidence level, human studies, sample sizes, design quality, outcomes, limitations, safety signals, and what is not proven.

Condition Evidence Setting What's not proven
Opioid use disorder Evidence: Moderateearly human and observational Observational detoxification reports, follow-up studies, and registered oral Ibogaine withdrawal research. Ibogaine is not proven to cure opioid addiction.
Alcohol use disorder Evidence: Moderateinvestigational FDA allowed an early phase U.S. Noribogaine hydrochloride study to proceed after an IND submission in April 2026. Noribogaine is not FDA-approved for alcohol use disorder.
Traumatic brain injury Evidence: Moderatenotable open label human signal A 30-person veteran prospective observational study and later neurophysiology work drew attention and require side-by-side design-limit explanation. Ibogaine is not proven as a general TBI treatment.
PTSD and trauma symptoms Evidence: Moderatesecondary outcomes and observational PTSD-related signals often appear within veteran or substance-use populations rather than standalone PTSD trials. Ibogaine is not proven as a PTSD treatment.
Depression and mood symptoms Evidence: Moderatesecondary outcomes and small reports Mood improvements appear in some Ibogaine-related observational and veteran studies, usually as secondary outcomes. Ibogaine is not proven as a depression treatment.
Parkinson's disease Evidence: Lowcase report watchlist A 2026 peer-reviewed case report describes one patient treated with low-dose Ibogaine hydrochloride over 80 days using validated Parkinson's instruments. Ibogaine is not proven as a Parkinson's treatment.
Withdrawal Evidence: Moderateearly human signal by context Withdrawal and craving findings appear in OUD studies, observational detoxification reports, and substance-use reviews. Craving reduction or withdrawal relief is not the same as a cure.
Cravings Evidence: Moderateearly human signal by context Withdrawal and craving findings appear in OUD studies, observational detoxification reports, and substance-use reviews. Craving reduction or withdrawal relief is not the same as a cure.