Evidence · condition
Opioid use disorder
LAST REVIEWED 2026-09-22 · OBSERVATIONAL / EARLY HUMAN · NOT A CURE
Landmark observational detoxification and follow-up reports exist. They are not FDA approval, not a cure claim, and not a reason to self-treat.
Is ibogaine proven for OUD?
No — not established as standard OUD care and not FDA-approved.
- Evidence level
- Early human / observational
- What is not proven
- Cure of opioid addiction; marketing approval
- Safety
- QTc · Denominators
- Self-treatment
- DIY refusal
What exists (source-labeled landmarks)
Alper KR et al., Am J Addict 1999. PMID 10506904, DOI 10.1080/105504999305848. Open-label case series — not an RCT. No dosing reproduced.
Brown TK, Alper K., Am J Drug Alcohol Abuse 2018. PMID 28541119, DOI 10.1080/00952990.2017.1320802. Observational — not confirmatory efficacy.
Mash DC et al., Ann N Y Acad Sci 2000. PMID 11085338, DOI 10.1111/j.1749-6632.2000.tb05213.x.
Mash DC et al., Alkaloids Chem Biol 2001. PMID 11705106, DOI 10.1016/s0099-9598(01)56012-5.
Malcolm BJ et al., J Psychoactive Drugs 2018. PMID 29608409, DOI 10.1080/02791072.2018.1447175. Open-label score changes — not RCT cure proof.
Registry adjacency: ClinicalTrials.gov NCT05029401 — not pivotal evidence or FDA approval. FDA FAQ.