Clinical boundary Schedule I in the U.S. Serious cardiac risk Not FDA-approved No dosing or referrals Schedule I · cardiac risk Not FDA-approved · no referrals

Sources

Source catalog

A public catalog of papers, trials, laws, policy records, podcasts, documentaries, books, cultural sources, claim records, and reference pages.

Sources indexed815
Podcasts and interviews 426
News, articles, and blogs 96
Laws and policy 77
State policy coverage 51
Studies and papers 44
Clinical trials 28
Clinics 20
Companies and patents 17
Books and bibliographies 16
Culture and stewardship 14
Reference pages 11
Evidence pages 8

Key people and institutions

These names are not endorsements. They are search anchors for modern history, research, policy, cultural scholarship, advocacy, guidelines, and public media context.

Modern-history figure

Howard Lotsof

1962 observation, advocacy, Dora Weiner Foundation, and patent history.

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Clinical researcher

Deborah Mash

Human Ibogaine research, public interviews, and treatment-development history.

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Researcher and reviewer

Kenneth Alper

Clinical literature, reviews, safety context, and history of Ibogaine research.

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Preclinical and analog research

Stanley Glick

18-MC and related preclinical development history.

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Anthropology and history

Giorgio Samorini

Public scholarship on Iboga cults, mythology, and early written records.

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Media and public history

Dimitri Mugianis

Documentary, harm-reduction, and public conversation history.

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Culture and policy resource

ICEERS

Community engagement, conservation, policy, and stewardship context.

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Guidelines and education

GITA

Global Iboga Therapy Alliance materials, guidelines, and public education history.

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Agency and registry sources

NIDA / FDA / ClinicalTrials.gov

Research, regulatory status, trial registration, and official public records.

Search records →
Open the people and institutions guide →

Source types

Youtube Video274

Journalism242

Podcast Interview143

State Policy Coverage Row51

Policy Tracker Row18

Peer Reviewed Study16

Clinical Trial Registry9

History Topic9

Condition Evidence Template8

Company Release4

Confidence labels

Media metadata418

Primary-source record274

State policy coverage row51

Peer-reviewed paper12

History topic9

Registry record9

Evidence framework7

Peer-reviewed source6

Claim record4

Cultural source4

People, organizations, and companies

Source-labeled records for the figures and organizations that recur across the catalog, including modern-history advocates, drug-development companies, guideline bodies, and conservation voices.

PersonConfidence: Moderate

Activism history

Dana Beal

Beal is a central figure in the U.S. ibogaine underground and its decades of public advocacy for ibogaine as an addiction-interruption tool.

  • Dana Beal is a longtime political activist who, through the group Cures-not-Wars, helped organize and publicize ibogaine as a proposed treatment for opioid dependence from the 1980s onward.
  • He is frequently described in journalism and reference sources as an ibogaine activist rather than a researcher or clinician.
  • His advocacy is part of the movement history around ibogaine, separate from the peer-reviewed evidence and the safety literature.

What this does not prove: Activist advocacy is not clinical evidence; his role in ibogaine history says nothing about whether ibogaine is safe or effective.

Source type: secondary review

Encyclopedic biography (secondary)

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PersonConfidence: Moderate

Modern-history figure

Norma Lotsof

Norma Lotsof helped carry Howard Lotsof's ibogaine work forward, including through the Dora Weiner Foundation, and belongs in modern advocacy history.

  • Norma Lotsof worked alongside Howard Lotsof and is associated with the Dora Weiner Foundation, the vehicle connected to Howard Lotsof's patents and advocacy.
  • She is a figure in ibogaine advocacy history, not a clinical-research source.

What this does not prove: Stewardship of an advocate's legacy is not evidence about ibogaine's safety or effectiveness.

Source type: secondary review

MAPS memorial context for Howard Lotsof (secondary)

Search records →
OrganizationConfidence: Moderate

Guidelines and education

Global Ibogaine Therapy Alliance (GITA)

GITA is a widely cited source of ibogaine safety and clinical-guideline material that a safety-first reference should track.

  • The Global Ibogaine Therapy Alliance (GITA) published Clinical Guidelines for Ibogaine-Assisted Treatment, a frequently cited document in ibogaine safety discussion.
  • Those clinical guidelines emphasize cardiac screening, medical monitoring, exclusion criteria, and emergency readiness.
  • IbogaBase describes GITA guidelines as source material, not as an IbogaBase-endorsed or IbogaBase-published protocol.

What this does not prove: Published guidelines are source material describing risk-management practice; they are not IbogaBase endorsement, not proof of efficacy, and not a protocol to follow.

Source type: org statement

GITA clinical guidelines (org statement)

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CompanyConfidence: Moderate

Commercial development

atai Life Sciences

atai is a major psychedelic biotech whose ibogaine and noribogaine ventures shape the commercial and analog-development conversation.

  • atai Life Sciences is a psychedelic biotech that, in January 2020, announced joint ventures with DemeRx to develop ibogaine and noribogaine for opioid use disorder.
  • atai ibogaine activity is a commercial and drug-development signal within the wider psychedelic biotech field, not clinical proof.
  • Business milestones and financing news are tracked separately from evidence and are not proof of effectiveness.

What this does not prove: Corporate investment, pipelines, and press releases do not establish clinical value, safety, or approval.

Source type: org statement

atai/DemeRx joint venture announcement (company release)

Search records →
CompanyConfidence: Moderate

Analog development

Savant HWP

Savant HWP is central to the 18-MC development history in the ibogaine-analog lane.

  • Savant HWP is the company associated with clinical-stage development of 18-MC (18-methoxycoronaridine), an ibogaine analog first characterized by Stanley Glick and Martin Kuehne.
  • The Savant HWP 18-MC program is part of the analog-development history, distinct from ibogaine itself.
  • Preclinical and early-stage analog work is not proof of human clinical benefit.

What this does not prove: Analog-development history does not make an analog interchangeable with iboga or ibogaine, and does not establish human efficacy.

Source type: secondary review

Alper KR, Ibogaine: a review (secondary review, PubMed)

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OrganizationConfidence: Moderate

Conservation and stewardship

Yann Guignon / Blessings of the Forest

Blessings of the Forest, associated with Yann Guignon, is a visible voice on Gabonese iboga conservation, cultivation, traceability, and benefit-sharing.

  • Blessings of the Forest, a Gabon-focused initiative associated with Yann Guignon, works on iboga conservation, sustainable cultivation, traceability, and benefit-sharing.
  • Its work is framed as conservation and stewardship, addressing wild-harvest pressure and access-and-benefit-sharing under the Nagoya Protocol.
  • IbogaBase cites Blessings of the Forest as a conservation voice, not as a lineage or ceremonial authority.

What this does not prove: Conservation advocacy does not confer lineage authority and is not a claim about ceremonial knowledge or medical outcomes.

Source type: org statement

ICEERS Iboga community engagement report (secondary)

Search records →

Conservation, sourcing, and benefit-sharing

Iboga accuracy depends on conservation and legal sourcing, not only clinical data. Public sources document wild-harvest pressure on Tabernanthe iboga in Gabon, cultivation efforts, and traceability of plant material from forest to product. Access-and-benefit-sharing under the Nagoya Protocol is the concrete legal instrument for Gabonese and community benefit, alongside conservation groups such as Blessings of the Forest. A "sustainable" or "ethical" sourcing label is a claim until traceability, current legal documentation, and benefit-sharing are shown.

Texas ibogaine funding, in primary-source terms

Texas Senate Bill 2308 (89th Legislature, 2025), authored by State Senator Tan Parker, directed a state-funded ibogaine clinical-research effort. In December 2025 the University of Texas Medical Branch (UTMB), with UTHealth Houston, was awarded $50 million by the state to lead ibogaine clinical trials. A funding appropriation and a trial program are not FDA approval, not treatment access, and not proof of effectiveness.

Mid-century and historical sources

Ibogaine's commercial and pharmacological history predates modern research. A Tabernanthe extract was sold in France as Lambarene, and the company CIBA studied ibogaine and related alkaloids in the mid-twentieth century. These are historical commercial and pharmacology records, not evidence of modern safety or effectiveness.

Coverage and known gaps

Completeness is part of trust. IbogaBase tracks a fixed set of canonical topics across history, culture, safety, law, evidence, and media, and shows which are covered, thin, or still being sourced. Where a topic cannot yet be sourced to a strong record, it is held out of public copy rather than filled with plausible-sounding text.

Canonical topics27

required history, culture, safety, law, and media coverage

Mapped0

visible or searchable in the current site

Under review1

known gaps or items needing stronger sources

Sources815

public records indexed for search

This coverage audit is a reader-facing view of the same obligations tracked in the IbogaBase integrity report. It flags what has been checked and what is still wanted; it is not legal, medical, or cultural certification.

Wanted sources

These are the gaps that would most improve the public reference.

Catalog preview

Source type: StudyConfidence: High

Magnesium-ibogaine therapy in veterans with traumatic brain injuries

Prospective open-label observational study of 30 male special-operations veterans who independently received magnesium-ibogaine treatment at Ambio Life Sciences in Mexico, with Stanford assessments before and after. The paper reports large short-term improvements and no unexpected serious adverse events, while stating that controlled clinical trials are needed.

Studies and papers · Nature Medicine

Source
Source type: StudyConfidence: High

Magnesium-ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury

Follow-up Nature Mental Health article on EEG and neural-complexity measures in the same broad magnesium-ibogaine veteran TBI research lane. It reports neurophysiological changes after treatment and states that controlled trials are needed to confirm findings.

Studies and papers · Nature Mental Health

Source
Source type: StudyConfidence: Low

Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis

Two-patient case report involving Ambio-affiliated authors and Ambio treatment records. Treat as preliminary case-report evidence with prominent conflict-of-interest and funder-involvement labels, not proof of efficacy.

Studies and papers · Frontiers in Immunology

Source
Source type: StudyConfidence: Moderate

Mapping Ibogaine Neural Dynamics in Opioid Use Disorder

ClinicalTrials.gov lists NCT07226570 as recruiting. A registry listing identifies a study and status; it is not safety, efficacy, approval, or treatment-access proof.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Ibogaine: Therapeutic Potential, Cardiac Safety, and Translational Challenges

Use as a synthesis source for therapeutic-potential claims, cardiac safety limits, and translational caution. It supports safety-first interpretation, not efficacy certainty.

Studies and papers · source_radar

Source
Source type: StudyConfidence: Low

Ibogaine for the treatment of Parkinson's disease: a case report

Track as exciting but very preliminary. One patient, low-dose course, validated PD instruments, no adverse events recorded, sleep worsened; not efficacy proof.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Accelerated recovery using magnesium ibogaine: subjective experience analysis

Qualitative analysis from the 30-person MISTIC veteran cohort; interpret alongside open-label design limits.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Mystical experiences during magnesium-Ibogaine associated with PTSD symptom improvements in veterans

Track as 30-male-veteran secondary analysis from MISTIC; association does not prove mechanism or general efficacy.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Magnesium-ibogaine therapy effects on cortical oscillations and neural complexity

Track as follow-on analysis from the veteran TBI research line.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Efficient and modular synthesis of ibogaine and related alkaloids

Important for supply, analog research, and non-plant-derived chemistry coverage.

Studies and papers · source_radar

Source
Source type: StudyConfidence: Moderate

A study of oral ibogaine in opioid withdrawal

Track recruitment/status, sponsor, eligibility criteria, and posted results.

Studies and papers · source_radar

Source
Source type: StudyConfidence: High

Veterans Say an Illegal Psychedelic Drug Is Helping Them. Now Mississippi Wants to Study Ibogaine. - Mississippi Free Press

Research source from Mississippi Free Press. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Mississippi Free Press

Source
Source type: CultureConfidence: High

Ibogaine’s Surge in Popularity Could Be a Huge Loss for the Gabonese People Unless We Shift Course - psychedelicalpha.com

Culture or stewardship source from psychedelicalpha.com. Outsider summaries require humility and source awareness.

Culture and stewardship · psychedelicalpha.com

Source
Source type: MediaConfidence: High

Ibogaine and addiction in the animal model, a systematic review and meta-analysis - Nature

News or commentary from Nature. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Nature

Source
Source type: StudyConfidence: High

Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis - Frontiers

Research source from Frontiers. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Frontiers

Source
Source type: StudyConfidence: High

Induction of insulin secretion by an aqueous extract of Tabernanhte iboga Baill. (Apocynaceae) in rat pancreatic islets of Langerhans - ScienceDirect

Research source from ScienceDirect. Study design, sample size, limitations, and safety signals matter.

Studies and papers · ScienceDirect

Source
Source type: StudyConfidence: High

Study Identifies Compounds Similar to Ibogaine That May Improve Treatment of Opioid Addiction - Association of American Universities (AAU)

Research source from Association of American Universities (AAU). Study design, sample size, limitations, and safety signals matter.

Studies and papers · Association of American Universities (AAU)

Source
Source type: StudyConfidence: High

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias - Wiley Online Library

Research source from Wiley Online Library. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Wiley Online Library

Source
Source type: MediaConfidence: High

A Texas hallucinogen hub? $100 million for ibogaine testing brings leading firm to Austin - Yahoo

News or commentary from Yahoo. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Yahoo

Source
Source type: MediaConfidence: Moderate

Ibogaine Detox Mexico: Powerful $6,000 Opioid Treatment

Covers Ibogaine Detox Mexico: Powerful $6,000 Opioid Treatment. This is a media source, not medical evidence.

Podcasts and interviews · PlacidWay Medical Tourism

Source
Source type: LawConfidence: High

Bush: Ibogaine saved my family - A Mississippi veteran’s perspective - tallahatchienews.ms

Law or policy source from tallahatchienews.ms. Read the exact source before drawing legal conclusions.

Laws and policy · tallahatchienews.ms

Source
Source type: StudyConfidence: High

Response to Luz & Mash on cardiac toxicity of ibogaine - Schellekens - 2022 - Addiction - Wiley Online Library

Research source from Wiley Online Library. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Wiley Online Library

Source
Source type: StudyConfidence: High

Clinical improvement following an integrative iboga microdosing protocol in post-concussive and hypoxic brain injury syndromes: a case series - Frontiers

Research source from Frontiers. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Frontiers

Source
Source type: StudyConfidence: High

Traditional opioid treatments are inadequate, but ibogaine research is an overpriced boondoggle - The Courier-Journal

Research source from The Courier-Journal. Study design, sample size, limitations, and safety signals matter.

Studies and papers · The Courier-Journal

Source
Source type: LawConfidence: High

Colorado lawmakers approve Ibogaine research bill - CBS News

Law or policy source from CBS News. Read the exact source before drawing legal conclusions.

Laws and policy · CBS News

Source
Source type: StudyConfidence: High

Kentucky Republican proposes studying psychedelic drug ibogaine to curb addiction - Hanford Sentinel

Research source from Hanford Sentinel. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Hanford Sentinel

Source
Source type: StudyConfidence: High

A Case of QT Prolongation and Torsades de Pointes Caused by Ibogaine Toxicity - ScienceDirect.com

Research source from ScienceDirect.com. Study design, sample size, limitations, and safety signals matter.

Studies and papers · ScienceDirect.com

Source
Source type: MediaConfidence: High

Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders | npj Mental Health Research - Nature

News or commentary from Nature. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Nature

Source
Source type: MediaConfidence: High

US speeds up research into mind-altering drugs — including mysterious ‘ibogaine’ - Nature

News or commentary from Nature. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Nature

Source
Source type: MediaConfidence: High

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models - Nature

Book or bibliography source from Nature. Interpret claims according to source type and evidence quality.

Books and bibliographies · Nature

Source
Source type: StudyConfidence: Moderate

New Frontiers in Psychedelic Research: Iboga Microdosing with Dr. Burton J. Tabaac & Teresa Yung

Research source from Psychedelic Vantage. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Psychedelic Vantage

Source
Source type: LawConfidence: High

Lawmakers hear from veterans, medical professionals as they consider the efficacy of Ibogaine - Magnolia Tribune

Law or policy source from Magnolia Tribune. Read the exact source before drawing legal conclusions.

Laws and policy · Magnolia Tribune

Source
Source type: StudyConfidence: High

University of Texas Medical Branch to receive $50M to study psychedelic ibogaine - The Daily News | Texas' Oldest Newspaper

Research source from The Daily News | Texas' Oldest Newspaper. Study design, sample size, limitations, and safety signals matter.

Studies and papers · The Daily News | Texas' Oldest Newspaper

Source
Source type: StudyConfidence: Moderate

#511: Hamilton Morris on Iboga, 5-MeO-DMT, The Power of Ritual, New Frontiers in Psychedelics, Excellent Problems to | The Tim Ferriss Show

Research source from 5 minute podcast summaries of: Tim Ferriss, Hidden Brain, Sam Harris, Lex Fridman, Jordan Peterson. Study design, sample size, limitations, and safety signals matter.

Studies and papers · 5 minute podcast summaries of: Tim Ferriss, Hidden Brain, Sam Harris, Lex Fridman, Jordan Peterson

Source
Source type: MediaConfidence: Moderate

Hamilton Morris chillstep—ibogaine

Covers Hamilton Morris chillstep—ibogaine. This is a media source, not medical evidence.

Podcasts and interviews · taylor gautreaux

Source
Source type: PrimaryConfidence: High

Psychedelic drug ibogaine hailed as healing. U.S. patients ask why it’s illegal. - The Washington Post

Company, patent, or biotech-field source from The Washington Post. Commercial claims need independent verification.

Companies and patents · The Washington Post

Source
Source type: MediaConfidence: Moderate

Ibogaine as a reset for addiction and weed policy

Covers Ibogaine as a reset for addiction and weed policy. This is a media source, not medical evidence.

Podcasts and interviews · Angry Me Production

Source
Source type: StudyConfidence: High

Sustained abstinence in severe ketamine use disorder following ibogaine treatment - Frontiers

Research source from Frontiers. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Frontiers

Source
Source type: MediaConfidence: High

Psychoactive drug ibogaine effectively treats traumatic brain injury in special ops military vets - Stanford Medicine

News or commentary from Stanford Medicine. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Stanford Medicine

Source
Source type: StudyConfidence: High

Texas to launch independent psychedelic study after drug companies miss mark - FOX 7 Austin

Research source from FOX 7 Austin. Study design, sample size, limitations, and safety signals matter.

Studies and papers · FOX 7 Austin

Source
Source type: StudyConfidence: High

Legislative updates in Mississippi, West Virginia, Oregon, and New Hampshire; Fast-tracked federal approval of Compass's synthetic psilocybin was vetoed; Federal bill proposes VA study psychedelics - The Microdose

Research source from The Microdose. Study design, sample size, limitations, and safety signals matter.

Studies and papers · The Microdose

Source
Source type: MediaConfidence: High

Psychedelic Stocks Rally After Trump’s Executive Order - Forbes

News or commentary from Forbes. Use it to understand public discussion and timing; verify important claims against primary sources.

News, articles, and blogs · Forbes

Source
Source type: StudyConfidence: High

Toward a nuanced framework for the medical development of ibogaine and its analogues and derivatives: implications for psychopharmacology.

Research source from Expert opinion on drug discovery. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Expert opinion on drug discovery

Source
Source type: StudyConfidence: High

Differential Impacts of Methadone and Buprenorphine/Naloxone on Pain-Related Outcomes Among People With Non-Heroin Opioid Use Disorder: Secondary Analyses From a Pragmatic Canadian Multisite Trial.

Research source from Drug and alcohol review. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Drug and alcohol review

Source
Source type: StudyConfidence: High

Thirty Years of Ibogaine Research: A Literature Review on Clinical Perspectives.

Research source from Journal of clinical psychopharmacology. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Journal of clinical psychopharmacology

Source
Source type: StudyConfidence: High

Blinding Integrity in Psychedelic Randomized Clinical Trials: A Systematic Review.

Research source from JAMA psychiatry. Study design, sample size, limitations, and safety signals matter.

Studies and papers · JAMA psychiatry

Source
Source type: StudyConfidence: High

The purpose of the psychosocial protocol in the psychedelic-assisted therapy: A scoping review.

Research source from Journal of psychopharmacology (Oxford, England). Study design, sample size, limitations, and safety signals matter.

Studies and papers · Journal of psychopharmacology (Oxford, England)

Source
Source type: StudyConfidence: High

Development and validation of a UPLC-MS/MS method for real-time neuropharmacokinetic monitoring of iboga alkaloids in rat brain.

Research source from Journal of pharmaceutical and biomedical analysis. Study design, sample size, limitations, and safety signals matter.

Studies and papers · Journal of pharmaceutical and biomedical analysis

Source

Related references